This study looks at the similarities and differences in functional connectivity changes in late-onset Alzheimer’s disease (LOAD), which is caused by rare genetic mutations in three specific genes, and autosomal dominant Alzheimer’s disease (ADAD), which has a more polygenetic risk profile.

Beau M. Ances, MD, PhD, of the Department of Neurology, Martinos Center for Biomedical Imaging, at the Massachusetts General Hospital and Harvard Medical School, in Boston, and colleagues, assessed the similarities and differences in functional connectivity changes owing to ADAD and LOAD in multiple brain resting state networks (RSNs) using resting-state functional connectivity magnetic resonance imaging at multiple international academic sites.

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