Strict Blood Pressure Control May Accelerate Cognitive Decline

Blood pressure
Blood pressure
In adults with cognitive impairment or dementia, low blood pressure may increase the rate of cognitive decline.

Antihypertensive regimens that perhaps work a little too well were linked to faster cognitive decline among older adults with pre-existing dementia or mild cognitive impairment (MCI) in a cohort study.

Patients in the lowest tertile of daytime systolic blood pressure (128 mmHg or less) showed a greater decline in Mini-Mental State Examination (MMSE) score over a median 9 months than those in the middle tertile (129 to 144 mmHg) or those in the top tertile of 145 mmHg or higher — mean -2.8 points on the 30-point MMSE scale versus -0.7 in both higher groups (P=0.002 and P=0.003, respectively).

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