Influenza Vaccination Can Reduce Risk of Guillain-Barré Syndrome

Vaccine
Vaccine
It's unclear whether the effect that the vaccine has on contracting influenza is responsible for the reduced risk.

It is unclear whether seasonal influenza vaccination results in a net increase or decrease in the risk for Guillain-Barré syndrome (GBS). To assess the effect of seasonal influenza vaccination on the absolute risk of acquiring GBS, we used simulation models and published estimates of age- and sex-specific risks for GBS, influenza incidence, and vaccine effectiveness.

For a hypothetical 45-year-old woman and 75-year-old man, excess GBS risk for influenza vaccination versus no vaccination was −0.36/1 million vaccinations (95% credible interval −1.22% to 0.28%) and −0.42/1 million vaccinations (95% credible interval, –3.68% to 2.44%), respectively.

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