HealthDay News — Botulinum toxin-A (BTX-A) may be beneficial for painful diabetic neuropathy (PDN), according to a meta-analysis published online in Pain Medicine.

Shaheen E. Lakhan, MD, PhD, from the Global Neuroscience Initiative Foundation in Los Angeles, and colleagues conducted a meta-analysis of two studies using BTX-A in the treatment of neuropathic pain. The difference in visual analog scale (VAS) from pre-intervention to one month post-intervention was measured as the primary outcome.

The researchers found that following treatment with BTX-A there was an improvement of 1.96 VAS points (P < 0.001), which corresponded to a clinically significant improvement of “minimum change in pain.” There was no statistically significant effect on adverse events in terms of infection at injection site (P = 0.49).

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“Tests for significance, low overall risk of bias, and almost no statistical heterogeneity suggests that there is a correlation between BTX-A and improvement of pain scores in PDN,” the authors write.


Lakhan SE et al. Pain Med. 2015; doi:10.1111/pme.12728.