Tramadol is a weak opioid analgesic whose use has increased rapidly, and it has been associated with adverse events of hypoglycemia.

Jean Pascal Fournier, MD, PhD, of Jewish General Hospital and McGill University in Montreal, and colleagues assessed whether tramadol use, when compared with codeine use, is associated with an increased risk of hospitalization for hypoglycemia.

A nested case-control analysis was conducted within the United Kingdom Clinical Practice Research Datalink linked to the Hospital Episodes Statistics database of all patients newly treated with tramadol or codeine for noncancer pain between 1998 and 2012. Cohort and case-crossover analyses were also conducted to assess consistency of the results.

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