Perinatal Maternal Depression Linked to Child Brain Development at 10 Years

Stressed mother and her baby.
Perinatal maternal depressive symptoms were consistently associated with brain development in offspring at age 10 years.

The presence of maternal depression symptoms in the perinatal period was associated with brain development in offspring at 10 years of age, according to a population-based study published in the American Journal of Psychiatry.

The study included data from 3469 mother-child pairs who were part of the Generation R Study, a longitudinal birth cohort in Rotterdam, The Netherlands. Investigators examined whether there was a connection between maternal depression and child brain development, using a validated self-report questionnaire to assess maternal depressive symptom patterns during pregnancy (20.6 weeks of gestation on average) and when the children were 2 months, 3 years, and 10 years old, followed by brain neuroimaging in the offspring at age 10 years.

Related Articles

Analyses revealed that exposure to maternal depressive symptoms at 2 months of age was associated with smaller total gray matter volume and lower global fractional anisotropy when comparing these measurements with those in children who were not exposed to maternal depression. Children with mothers who scored highest in depression symptoms during the perinatal period had less gray matter and lower white matter fractional anisotropy than children who were not exposed to maternal depression. These associations were not present at the other points. In addition, results suggest that differences in gray matter volume mediated the association between maternal depressive symptoms at 2 months and childhood attention problems at 10 years.

Because only cross-sectional neuroimaging data were used, researchers could not determine whether the effects were permanent or transient. In addition, the prevalence of depression was low in the cohort, limiting researchers’ ability to detect an association. They cautioned, “The results must be generalized carefully to more vulnerable populations.”

The investigators concluded, “Maternal depressive symptoms in the perinatal period, in particular the postnatal period, are more likely to affect offspring brain development, which suggests a critical period of sensitivity.”

See source for complete disclosure information.


Zou R, Tiemeier H, van der Ende J, et al. Exposure to maternal depressive symptoms in fetal life or childhood and offspring brain development: a population-based imaging study [published online May 6, 2019]. Am J Psychiatry. doi:10.1176/appi.ajp.2019.18080970

This article originally appeared on Psychiatry Advisor