HealthDay News — Nocturnal arousal burden (AB) is associated with long-term cardiovascular (CV) and overall mortality among women and possibly among men, according to a study published online April 20 in the European Heart Journal.

Sobhan Salari Shahrbabaki, Ph.D., from the University of Adelaide in Australia, and colleagues quantified AB in three cohort studies by measuring the AB on overnight polysomnograms of 2,782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF), and 2,221 men and 2,574 women in the Sleep Heart Health Study (SHHS).

The researchers found that 665 men died, including 236 CV deaths, during 11.2 years of follow-up in MrOS; 105 women died, including 47 CV deaths, during 6.4 years of follow-up in SOF; and 987 participants died, including 344 CV deaths, during 10.7 years of follow-up in SHHS. After adjustment for common confounders, in women, AB was associated with all-cause mortality (SOF: hazard ratio, 1.58; SHHS women: hazard ratio, 1.21) and CV mortality (SOF: hazard ratio, 2.17; SHHS women: hazard ratio, 1.60). The association between AB and all-cause and CV mortality was less clear in men.


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“Even though many knowledge gaps on the relationship between sleep and CVD remain to be studied in the coming years, this study provides solid evidence supporting the importance of sleep quality for a better CV health,” write the authors of an accompanying editorial.

Abstract/Full Text

Editorial