HealthDay News — People who are resistant to aspirin may be at risk for larger, more severe strokes, according to a study scheduled to be presented at the upcoming annual meeting of the American Academy of Neurology in April. 

“Aspirin resistance is an important predictor of severe stroke and large stroke size in patients taking aspirin before having a stroke,” lead researcher Mi Sun Oh, MD, of the department of neurology at the Hallym University College of Medicine in Seoul, South Korea, told HealthDay. “In patients at high risk for stroke with aspirin resistance, different anti-clotting drugs — such as clopidogrel (Plavix) — can be considered as alternatives to prevent another stroke or decrease stroke severity.”

For the study, Oh and colleagues studied 310 patients who had been taking aspirin for at least seven days before they suffered an ischemic stroke. Aspirin resistance was checked within 24 hours of hospital admission.

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The researchers found that 27.7% of the patients were resistant to aspirin. Their strokes ranged from three to 11 on a stroke severity score, compared with scores of one to six among aspirin responders. Moreover, strokes of patients resistant to aspirin affected about twice the brain area as the strokes of those who responded to aspirin.