HealthDay News — The Recurrence Risk Estimator (RRE) score is valid for identifying the risk of recurrence in patients with acute ischemic stroke, according to a study published in JAMA Neurology.

E. Murat Arsava, MD, from the Hacettepe University Faculty of Medicine in Ankara, Turkey, and colleagues examined the validity of a prognostic score to predict early risk of stroke recurrence. The study was performed at 3 teaching hospitals in the United States, Brazil, and South Korea; 1468 adult patients admitted within 72 hours of acute ischemic stroke were enrolled. The RRE score was calculated for each patient by an investigator who was blinded to recurrence status.

The researchers found that there were 59 recurrent stroke events within the cohort. The cumulative 90-day recurrence rate was 4.2%, with a mean RRE score of 2.2 in patients with recurrence and 1.0 in patients without recurrence. Increased risk of recurrence was observed with a higher RRE score (log-rank test, P < 0.001). For discrimination, the area under the receiver operating characteristic curve was 0.76. The RRE identified 48.4% of patients as high or low risk. The sensitivity and specificity were 38 and 93%, respectively, and 41 and 90%, respectively, for identifying low-risk and high-risk subsets.

“Our findings suggest that the RRE could be useful in identifying high- and low-risk patients for targeted stroke prevention,” the authors write.


Arsava EM, Kim GM, Oliveira-filho J, et al. Prediction of Early Recurrence After Acute Ischemic Stroke. JAMA Neurol. 2016; doi: 10.1001/jamaneurol.2015.4949.