HealthDay News — Patients who suffer a stroke are more likely to experience accelerated decline of global cognition and executive function for at least six years after the event, according to a report published in the Journal of the American Medical Association.

The study, led by Deborah Levine, MD, MPH, an assistant professor at the University of Michigan Medical School and a staff physician with the Ann Arbor VA Healthcare System, focused on 23,572 participants in a larger U.S. National Institutes of Health-sponsored project that’s examining regional and racial differences in stroke mortality. The participants were 45 or older with no baseline cognitive impairment. Five hundred fifteen participants suffered a stroke during an average six-year follow-up period.

The researchers found that after the stroke, patients suffered a significantly faster rate of long-term cognitive decline compared with their pre-stroke rate. The decline mainly centered around two domains primarily affected by stroke: global cognition and executive function. However, stroke did not seem to cause a long-term change in verbal memory, or the ability to learn new things.

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For every year following a stroke, patients have a 23% greater risk of suffering additional cognitive impairment, compared to how they would have fared if they never had a stroke, Levine told HealthDay. “We found that stroke survivors had a significantly faster rate of developing new cognitive impairment following their stroke, compared to their pre-stroke rates,” she said.


  1. Levine DA et al. JAMA. 2015; doi:10.1001/jama.2015.6968.