HealthDay News — Patients with hip fracture have an increased risk of myocardial infarction (MI) and stroke, according to a study published in the Journal of Bone and Mineral Research.

Alma B. Pedersen, MD, PhD, from Aarhus University Hospital in Denmark, and colleagues examined the interaction between hip fracture and comorbidity with respect to risks of MI or stroke using data for 110,563 hip fracture patients and 552,774 individuals from the general population.

The researchers found that the 30-day cumulative incidences of MI were 1.15% and 0.09% among patients with hip fracture and the general population, respectively (adjusted hazard ratio [aHR], 12.97; 95% confidence interval [CI], 11.56-14.55). The 30-day cumulative incidences of stroke were 2.16% and 0.21% for patients with hip fracture and the general population (aHR, 9.42; 95% CI, 8.71-10.19). 

The aHR for MI was 1.05 (95% CI, 0.97-1.14) between 31 and 365 days after hip fracture and remained at this level during a maximum follow-up of 20 years. For stroke, the aHR was 1.29 (95% CI, 1.22-1.35) between 31 and 365 days after hip fracture, remained elevated for 10 years, and then decreased to the level of the general population.

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“Our finding underscores the importance of targeting multimorbidity, including prevention and adequate treatment, to improve the prognosis of hip fracture patients,” the authors write.


Pedersen AB, Ehrenstein V, Szépligeti SK, Sørensen HT. Hip fracture, comorbidity, and the risk of myocardial infarction and stroke: a Danish nationwide cohort study, 1995-2015 [published online August 21, 2017]. J Bone Miner Res. doi:10.1002/jbmr.3242