Researchers from the U.K. sought to understand the effects of medications with anticholinergic properties on people with existing brain or spinal injuries. Anticholinergics are used broadly to treat common complications, from incontinence to depression, and are associated with side effects including temporary cognitive impairment, dizziness, and confusion. 

The observational study included 52 patients with acquired brain or spinal injuries from a U.K. rehabilitation hospital. Researchers found a statistically significant correlation between anticholinergic burdern and neuro-disability measures and length of stay among the patient cohort. 

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