Elevated Tau After Multiple TBI Linked to Chronic Post-Concussive Symptoms

Brain connections
Brain connections
Elevated levels of plasma tau appear to persist after multiple TBIs, contributing to chronic symptoms.

Approximately one-third of military personnel who deploy for combat operations sustain 1 or more traumatic brain injuries (TBIs), which increases the risk for chronic symptoms of postconcussive disorder, posttraumatic stress disorder, and depression and for the development of chronic traumatic encephalopathy. Elevated concentrations of tau are observed in blood shortly following a TBI, but, to our knowledge, the role of tau elevations in blood in the onset and maintenance of chronic symptoms after TBI has not been investigated.

Researchers assessed peripheral tau levels in military personnel exposed to TBI and examined the relationship between chronic neurological symptoms and tau elevations.

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