Head Injuries at Young Age May Disrupt Brain Development

HealthDay News — Earlier exposure to repetitive head impacts in former professional football players correlates with later-life altered corpus callosum (CC) microstructure, according to a study published in the Journal of Neurotrauma.

Julie M. Stamm, PhD, from the Boston University School of Medicine, and colleagues used magnetic resonance diffusion tensor imaging to examine the correlation between age of first exposure (AFE) to repetitive head impacts (RHI) through tackle football and later-life CC microstructure. Data were included from 40 retired National Football League (NFL) players, aged 40 to 65 years, who were divided into two groups based on their AFE to tackle football: before age 12 or at age 12 or older. Deterministic tractography was used to define and seed the whole CC and five subregions.

The researchers found that former NFL players in the AFE <12 group versus the ≥12 group had significantly lower fractional anisotropy in anterior three CC regions and had higher radial diffusivity in the most anterior CC region.

“These results suggest that incurring RHI during critical periods of CC development may disrupt neurodevelopmental processes, including myelination, resulting in altered CC microstructure and greater vulnerability to aging processes,” the authors write.

One author disclosed financial ties to the medical device industry and serves as an expert adviser to attorneys in cases pertaining to the long-term consequences of repetitive brain trauma.


  1. Stamm JM et al. J Neurotrauma. 2015; doi:10.1089/neu.2014.3822