Cerebral Blood Flow Reduction from Microbleeds Causes Cognitive Deficits

Brain blood vessels
Brain blood vessels
Cerebral microbleeds (CMBs) are a common MRI finding in elderly patients, and are associated with cognitive deficits.

Cerebral microbleeds (CMBs) are collections of blood breakdown products that are a common incidental finding in magnetic resonance imaging of elderly individuals. Cerebral microbleeds are associated with cognitive deficits, but the mechanism is unclear. Studies show that individuals with CMBs related to symptomatic cerebral amyloid angiopathy have abnormal vascular reactivity and cerebral blood flow (CBF), but, to our knowledge, abnormalities in cerebral blood flow have not been reported for healthy individuals with incidental CMBs.

Researchers evaluated the association of incidental CMBs with resting-state CBF, cerebral metabolism, cerebrovascular disease, β-amyloid (Aβ), and cognition.

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