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TROGARZO
Viral infections
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Drug Name:

TROGARZO Rx

Generic Name and Formulations:
Ibalizumab-uiyk 200mg/1.33mL; soln for IV inj after dilution; preservative-free.

Company:
Theratechnologies Inc.

Therapeutic Use:

RECENT UPDATES

Monograph added.

Indications for TROGARZO:

In combination with other antiretroviral(s) for HIV-1 infection in heavily treatment-experienced adults with multidrug resistant HIV-1 infection failing their current antiretroviral regimen.

Adult:

Give as IV infusion over ≥30mins for first infusion; may reduce to ≥15mins for subsequent infusions if no infusion-associated adverse reactions have occurred. 2000mg as single loading dose followed by 800mg maintenance dose every 2 weeks.

Children:

Not established.

Warnings/Precautions:

Do not administer as IV push or bolus. Observe patient for 1hr post-infusion; may reduce to 15mins thereafter if no infusion-associated adverse reactions have occurred. Pregnancy. Nursing mothers: not recommended.

Pharmacological Class:

CD4-directed post-attachment HIV-1 inhibitor.

Adverse Reactions:

Diarrhea, dizziness, nausea, rash; immune reconstitution inflammatory syndrome.

Note:

To register pregnant patients to the Antiretroviral Pregnancy Registry, call (800) 258–4263.

Generic Availability:

NO

How Supplied:

Single-dose vials (2mL)—2

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