ZITHROMAX INJECTION Rx
Generic Name and Formulations:
Azithromycin 500mg/vial; for IV infusion after reconstitution and dilution.
Indications for ZITHROMAX INJECTION:
Susceptible infections including community-acquired pneumonia, pelvic inflammatory disease (PID).
Give by IV infusion 1mg/mL over 3hrs or 2mg/mL over 1hr. ≥16yrs: Pneumonia: 500mg once daily for at least 2 days, switch to 500mg orally once daily, for a total of 7–10 days combined therapy. PID: 500mg once daily for 1–2 days, switch to 250mg orally once daily for a total of 7 days combined therapy.
<16yrs: not established.
Ketolide allergy. History of cholestatic jaundice/hepatic dysfunction associated with prior use.
Pneumonia: oral treatment is for mild, community-acquired cases suitable for outpatient therapy only. Discontinue if signs/symptoms of hepatitis occur. Known QT prolongation, proarrhythmic conditions, clinically significant bradycardia: avoid. Allergic symptoms may recur after initial successful symptomatic treatment. Myasthenia gravis. Hepatic or renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers.
Avoid concomitant aluminum- or magnesium-containing antacids. Monitor with digoxin, phenytoin, warfarin. Monitor for azithromycin toxicity (eg, liver dysfunction, ototoxicity) with nelfinavir. Concomitant Class 1A (eg, quinidine, procainamide), or Class III (eg, dofetilide, amiodarone, sotalol) antiarrhythmics, or others known to prolong the QT interval: avoid.
Diarrhea, nausea, abdominal pain, vomiting, rash; hepatotoxicity, hypersensitivity reactions (eg, angioedema, AGEP, Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS; discontinue if occurs), torsade de pointes (esp. elderly), C. difficile associated diarrhea.
Biliary (primarily), renal.
Tabs—30; Z-Pak (6 x 250mg tabs)—3; Tri-Pak (3 x 500mg tabs)—3; Susp 100mg/5mL—15mL; 200mg/5mL—15mL, 22.5mL, 30mL; Single Dose Packets—3, 10; Inj—10
Neurology Advisor Articles
- FDA Approves Aimovig for Migraine Prevention
- Prediction Algorithm Stratifies ICH Patients at Risk for Hematoma Expansion
- Sports-Related Concussion Outcomes Predicted With Serum Neurofilament Light
- FDA Fast-Tracks Treatment for Autism Spectrum Disorder
- Psychological Therapies May Help Older Adults With Chronic Pain
- Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients
- Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects
- Risk of Dementia Up for Older Adults With Lowest Wealth
- Language Used in Medical Record Can Affect Patient Care
- Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics